Não quero que seja apenas mais um trabalho, gostava de sensibilizar quem lê o meu Blog para este problema presente nos nossos tempos e ainda tão distante de ter uma cura!



Schizophrenia is a psychosis, a disorder of thought and sense of self. Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. There is no characteristic pathology, such as neurofibrillary tangles in Alzheimer disease (104300). Schizophrenia is a common disorder with a lifetime prevalence of approximately 1%. It is highly heritable but the genetics are complex. This may not be a single entity.



Schizophrenia is treated chiefly with dopamine antagonists. Atypical antipsychotic drugs such as clozapine have been introduced in an effort to avoid extrapyramidal side effects resulting from prolonged use of dopamine antagonists.

Basile et al. (2002) discussed the role of genetic polymorphisms in predicting responsiveness to pharmacotherapeutic agents in schizophrenia. They focused on genetic variants in the dopamine receptor genes and clinical response to clozapine.

If a narrow diagnostic definition is used, the lifetime morbid risk of schizophrenia does not vary far from 1% (range 0.7% to 1.4%) in a wide variety of geographic regions (Jablensky et al., 1992). A higher incidence has been found in certain populations (Book et al., 1978).

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